There is a connection between cluster headaches and magnesium and that is why there are doctor’s that prescribe a supplement with magnesium for cluster headaches, but what is exactly the connection between the two? The most accepted response would be that there are receptor sites in the brain that magnesium will bind to. These sites are known to be very excitatory in nature and the binding with the magnesium appears to calm them down. Severe lack of magnesium in the brain has been known to cause everything from apathy to psychosis in psychiatric conditions and can even cause seizures.

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